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KMID : 0358819790060010051
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1979 Volume.6 No. 1 p.51 ~ p.64
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Comparative Study of Biological Dressings on Open Wound Healing in Rabbits
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Lee Duk-Hee
Ha Ji-Won
Lee Young-Kil
Kang Jin-Sung
Jung Jae-Hong
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Abstract
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The principal objectives of treating open infected wound or burns are the early removal of necrotic tissue and adequate wound coverage constituting variable methods of temporary biological dressings.
Temporary biological dressings are essential and life saving for large skin defects until permanent repair with autografts or isograft can be instituted.
Since early times, several attempts of variable temporary biological dressings were used for wound coverage which included allografts and xenografts, some successful, some unsuccessful.
We used healthy rabbits in the study of comparing biological dressings.
The backs of 20 rabbits were shaved and each rabbit had 6 wounds measuring 3×3cm. The rabbit were divided into 2 groups, group Ⅰ had split thickness defects and group Ⅱ had full thickness skin defects.
By using aseptic technique, through an abdominal incision, rabbit amniotic membrane was obtained from the placenta, the membrane was cleansed with sterile isotonic saline solution and 0.025% sodium hypochlorite solution for sterilization prior to being applied on each wound.
Human amniotic membrane was obtained from placenta by easily peeling it from the chorion and was prepared by the same method as the rabbit amniotic membrane.
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